高血压易感和抗性大鼠后脑核中的儿茶酚胺和血管加压素

Catecholamines and vasopressin in hindbrain nuclei of hypertension prone and resistant rats.

作者信息

Feuerstein G, Zerbe R L, Ben-Ishay D, Kopin I J, Jacobowitz D M

出版信息

Brain Res. 1982 Nov 11;251(1):169-73. doi: 10.1016/0006-8993(82)91286-0.

PMID:7172001

Abstract

Norepinephrine and epinephrine concentrations in the caudal and rostral part of the nucleus tractus solitarii (NTS) and in locus coeruleus (LC) of Sabra hypertension prone (SBH) rats are 2-4-fold higher than in the parent Sabra (SB) strain; SB rats have higher concentrations than the Sabra hypertension resistant (SBN) rats. Dopamine concentrations were higher in SBH as compared to SB and SBN rats only in the caudal NTS. Vasopressin concentrations in the NTS of SBH were 3-fold higher than the levels found in SB or SBN rats. These data suggest that catecholamines and vasopressin in specific brainstem nuclei are involved in either the pathogenesis or central response to hypertension in SBH rats.

摘要

在易患高血压的Sabra大鼠（SBH）的孤束核（NTS）尾端和头端以及蓝斑（LC）中，去甲肾上腺素和肾上腺素的浓度比亲代Sabra（SB）品系高2至4倍；SB大鼠的浓度高于抗高血压的Sabra大鼠（SBN）。仅在NTS尾端，与SB和SBN大鼠相比，SBH大鼠的多巴胺浓度更高。SBH大鼠NTS中的血管加压素浓度比SB或SBN大鼠中的水平高3倍。这些数据表明，特定脑干核中的儿茶酚胺和血管加压素参与了SBH大鼠高血压的发病机制或中枢反应。