Maciewicz R, Phipps B S, Bry J, Highstein S M
Brain Res. 1982 Dec 2;252(1):1-11. doi: 10.1016/0006-8993(82)90973-8.
Axoplasmic transport techniques were used to determine the contribution of the ascending tract of Deiters (ATD) to the vestibulothalamic projection in cats. Large injections of HRP into the thalamus centered on the border region between the ventrobasal complex and the caudal ventrolateral nucleus resulted in bilateral retrograde labeling of cells in the vestibular nuclear complex and the nucleus prepositus hypoglossi (PH). Similar thalamic injections were also made in animals with extensive bilateral lesions of the medial longitudinal fasciculus (MLF) and the brachium conjunctivum (BC). HRP-positive neurons in these cases were localized principally to the ventral lateral vestibular nucleus and adjacent superior vestibular nucleus ipsilateral to the thalamic injection, evidence that vestibulothalamic neurons in these nuclei may project to the thalamus over the unlesioned ATD. Injections of [35S]methionine into the rostral vestibular nuclear complex in animals with MLF and BC lesions confirmed these findings, demonstrating orthograde transport of radiolabel in the ATD with termination in thalamus. These experiments document a contribution of the ATD to the ipsilateral vestibulothalamic projection; other sources of the vestibulothalamic pathway (PH, Y group) likely travel through projection systems destroyed in the lesions made in the present study.
采用轴浆运输技术来确定猫中代特氏升束（ATD）在前庭丘脑投射中的作用。在前庭丘脑投射中，将大量辣根过氧化物酶（HRP）注射到丘脑，注射部位集中在腹侧基底复合体和尾侧腹外侧核之间的边界区域，结果在前庭神经核复合体和舌下前置核（PH）中出现了双侧逆行标记细胞。在患有内侧纵束（MLF）和结合臂（BC）广泛双侧损伤的动物中也进行了类似的丘脑注射。在这些情况下，HRP阳性神经元主要定位于丘脑注射同侧的腹外侧前庭核和相邻的上前庭核，这表明这些核中的前庭丘脑神经元可能通过未受损的ATD投射到丘脑。在患有MLF和BC损伤的动物中，将[35S]甲硫氨酸注射到前庭神经核复合体的头端，证实了这些发现，显示了放射性标记物在ATD中的顺行运输并终止于丘脑。这些实验证明了ATD对同侧前庭丘脑投射的作用；前庭丘脑通路的其他来源（PH、Y组）可能通过在本研究中所造损伤中被破坏的投射系统传导。
