Moghimzadeh E, Nobin A, Rosengren E
Brain Res Bull. 1982 Jul-Dec;9(1-6):709-14. doi: 10.1016/0361-9230(82)90176-9.
The finding of an adrenergic innervation of the liver parenchyma in many mammalian species, using the Falck-Hillarp fluorescence method, together with the electron microscopy documentation of synaptoid contacts between adrenergic nerve terminals and hepatocytes, constitute an important morphological basis for the possibility of a direct role of the sympathetic nervous system on the liver function. The results from the morphological studies are in accordance with physiological experiments, carried out in many laboratories, showing that direct electrical stimulation of the hepatic nerves in vivo leads to an increased release of glucose from the hepatocytes. These findings have augmented the demand for detailed studies of the receptor systems mediating the effects of catecholamines on liver metabolism. Our pharmacological studies on liver tissue in vitro have revealed a predominant role for adrenergic betareceptors mediating glucose output in man.
运用法尔克-希拉尔普荧光法，在许多哺乳动物物种中发现肝实质存在肾上腺素能神经支配，同时通过电子显微镜记录了肾上腺素能神经末梢与肝细胞之间的突触样接触，这为交感神经系统对肝功能可能具有直接作用提供了重要的形态学依据。形态学研究结果与许多实验室进行的生理学实验一致，这些实验表明，在体内直接电刺激肝神经会导致肝细胞释放葡萄糖增加。这些发现增加了对介导儿茶酚胺对肝脏代谢影响的受体系统进行详细研究的需求。我们对体外肝脏组织的药理学研究表明，肾上腺素能β受体在介导人体葡萄糖输出方面起主要作用。
