Blomgren I, Eriksson E, Bagge U
Burns Incl Therm Inj. 1982 Sep;9(1):17-20. doi: 10.1016/0305-4179(82)90130-9.
One ear of adult white NMRI hairy mice was first scalded and then immersed in cold water in order to study the effect of cooling on oedema formation. Oedema was determined by wet-dry weight measurements of punch biopsies from the ear and expressed as an increase in tissue water content. The temperature of the cold water was 8 degrees C and periods of cooling from 15 to 240 minutes were used. The contralateral ear and the quadriceps muscle were used to study distant effects of scalding and cooling. After scalding, significant oedema was found in the burned ear. Cooling for 30 minutes gave a significant reduction of oedema in this model. Shorter or longer periods of cooling did not reduce oedema significantly. Cooling did not influence the oedema formation of the contralateral (unburned ear). Neither scalding nor cooling changed the water content of the muscle.
为了研究冷却对水肿形成的影响，对成年白色NMRI多毛小鼠的一只耳朵先进行烫伤，然后浸入冷水中。通过对耳部打孔活检组织进行湿重与干重测量来确定水肿情况，并以组织含水量的增加来表示。冷水温度为8摄氏度，冷却时间为15至240分钟。使用对侧耳朵和股四头肌来研究烫伤和冷却的远处效应。烫伤后，在烫伤的耳朵中发现明显水肿。在该模型中，冷却30分钟可使水肿显著减轻。较短或较长时间的冷却均未显著减轻水肿。冷却并未影响对侧（未烫伤耳朵）的水肿形成。烫伤和冷却均未改变肌肉的含水量。
