Nylander G, Nordström H, Eriksson E
Burns Incl Therm Inj. 1984 Feb;10(3):193-6. doi: 10.1016/0305-4179(84)90026-3.
Hyperbaric oxygen (HBO) has been advocated as an adjuvant in the therapy of thermal burns. One of the positive effects was reported to be a decrease in fluid requirements. The effect of HBO on oedema formation was evaluated in the burned area and in distant areas. Fifty-four mice were used in a standardized scald burn model, burning their left ear. Biopsies were taken from the left and right ear and from the quadriceps muscle 2, 6 and 24 hours after burn. Half of the group was treated with HBO immediately after burn. In the burned HBO treated group the oedema of the burned ear was not significantly different from that of burned untreated mice. With HBO treatment the water content in the contralateral ear was significantly (P less than 0.01) lower and in these animals the water content of the contralateral uninjured ear was not significantly different from that of uninjured untreated animals. In the burned HBO treated animals there was a significantly (P less than 0.05) lower water content of the quadriceps muscle 2 and 24 hours after burn compared to the burned untreated animals. This experimental study indicates a significant reduction of the general post-burn oedema with a HBO treatment.
高压氧（HBO）已被提倡作为热烧伤治疗的辅助手段。据报道其积极作用之一是减少液体需求量。评估了HBO对烧伤部位和远处部位水肿形成的影响。在标准化的烫伤模型中使用54只小鼠，烫伤它们的左耳。在烧伤后2小时、6小时和24小时从左耳、右耳和股四头肌取活检样本。该组一半的小鼠在烧伤后立即接受HBO治疗。在接受HBO治疗的烧伤组中，烧伤耳朵的水肿与未治疗的烧伤小鼠相比无显著差异。经HBO治疗后，对侧耳朵的含水量显著降低（P小于0.01），并且在这些动物中，对侧未受伤耳朵的含水量与未治疗的未受伤动物相比无显著差异。与未治疗的烧伤动物相比，接受HBO治疗的烧伤动物在烧伤后2小时和24小时股四头肌的含水量显著降低（P小于0.05）。这项实验研究表明，HBO治疗可显著减轻烧伤后的全身性水肿。
