von Slooten H, van Seters A P, Smeenk D, Moolenaar A J
Cancer Chemother Pharmacol. 1982;9(2):85-8. doi: 10.1007/BF00265384.
The distribution of o,p'-DDD in various body compartments of patients being treated for metastatic adrenocortical carcinoma was studied. A highly significant semilogarithmic relationship was found between plasma and adipose tissue concentrations during therapy and between plasma and brain at autopsy. A linear relationship was found at autopsy between concentrations in adipose tissue and those in various other tissues, such as tumour and brain. The semilogarithmic relationship can be explained by the assumption of two plasma pools for o,p'-DDD, one with low affinity and high capacity and one with high affinity and low capacity. Plasma concentrations must be carefully monitored to obtain an impression of the tumour concentration and to detect impending central nervous system intoxication.
对接受转移性肾上腺皮质癌治疗的患者体内各身体腔室中邻对滴滴滴（o,p'-DDD）的分布进行了研究。在治疗期间，血浆与脂肪组织浓度之间以及尸检时血浆与脑之间发现了高度显著的半对数关系。尸检时发现脂肪组织与其他各种组织（如肿瘤和脑）中的浓度之间呈线性关系。这种半对数关系可以通过假设o,p'-DDD存在两个血浆池来解释，一个具有低亲和力和高容量，另一个具有高亲和力和低容量。必须仔细监测血浆浓度，以了解肿瘤浓度情况并检测即将发生的中枢神经系统中毒。
