Moolenaar A J, van Slooten H, van Seters A P, Smeenk D
Cancer Chemother Pharmacol. 1981;7(1):51-4. doi: 10.1007/BF00258213.
Plasma levels of o,p'-DDD were measured after ingestion of a single oral dose. At the onset of therapy o,p'-DDD was administered as commercially available tablets and granules and in milk, chocolate, and an oil emulsion to 9, 12, 14, 10, and 6 patients, respectively. Following administration in chocolate, emulsion, and milk significantly higher mean plasma levels were recorded in the first 5- and 10-h periods than after tablets. Granules gave significantly lower plasma levels than all other forms. Plasma levels were also measured during maintenance therapy, when a total of 200 g o,p'-DDD was administered to 22 patients with adrenocortical carcinoma. The plasma disappearance rate after termination of long-term therapy was found to be between 18 and 159 days. The recovery of o,p'-DDD from faeces was about five times higher after ingestion of tablets than after administration in oil emulsion and milk. As far as the rapid increase in plasma levels and patient compliance are concerned, the best results were obtained with the milk powder mixture.
单次口服给药后测定了o,p'-DDD的血浆水平。治疗开始时，分别向9名、12名、14名、10名和6名患者以市售片剂、颗粒剂以及混入牛奶、巧克力和油乳剂的形式给予o,p'-DDD。在巧克力、乳剂和牛奶中给药后，前5小时和10小时的平均血浆水平明显高于片剂给药后。颗粒剂的血浆水平明显低于所有其他剂型。在维持治疗期间也测定了血浆水平，当时共向22例肾上腺皮质癌患者给予了200 g o,p'-DDD。长期治疗终止后的血浆清除率为18至159天。摄入片剂后从粪便中回收的o,p'-DDD比在油乳剂和牛奶中给药后高约五倍。就血浆水平的快速升高和患者依从性而言，奶粉混合物取得了最佳效果。
