Griner P F, Oranburg P R
Am J Clin Pathol. 1978 Nov;70(5):748-52. doi: 10.1093/ajcp/70.5.748.
The probabilities of low transferrin saturation, folic acid, or vitamin B12 levels in association with various erythrocyte indices was determined from the prevalences of these abnormalities and the distributions of the indices among 206 hospitalized and 1,000 ambulatory anemic patients. At mean corpuscular hemoglobin (MCH) greater than 30 pg, the probability of low transferrin saturation was 0.04 for hospitalized patients and 0.14 for ambulatory anemic patients. For MCH less than 27 pg, the corresponding probabilities were 0.52 and 0.67. The probabilities of low vitamin B12 or folic acid levels among hospitalized anemic patients were 0.0011 for mean corpuscular volume (MCV) less than 95 cu micron and 0.18 for MCV greater than or equal to 95 cu micron, indicating that measurements of these vitamins are of very limited value in most cases of anemia. These findings indicate that in some patients, the erythrocyte indices are sufficiently predictive for or against deficiency states to facilitate decisions regarding further diagnostic tests, as opposed to the increasing tendency to order such tests regardless of the indices.
根据这些异常情况的患病率以及206名住院贫血患者和1000名门诊贫血患者的各项指标分布，确定了转铁蛋白饱和度低、叶酸或维生素B12水平低与各种红细胞指数相关的概率。平均红细胞血红蛋白（MCH）大于30 pg时，住院患者转铁蛋白饱和度低的概率为0.04，门诊贫血患者为0.14。MCH小于27 pg时，相应概率分别为0.52和0.67。住院贫血患者中维生素B12或叶酸水平低的概率，平均红细胞体积（MCV）小于95立方微米时为0.0011，MCV大于或等于95立方微米时为0.18，这表明在大多数贫血病例中，检测这些维生素的价值非常有限。这些发现表明，在某些患者中，红细胞指数足以预测是否存在缺乏状态，从而有助于做出关于进一步诊断测试的决策，而不是不顾指标而越来越倾向于进行此类测试。
