Koch K L, Curry R C, Feldman R L, Pepine C J, Long A, Mathias J R
Dig Dis Sci. 1982 Dec;27(12):1073-80. doi: 10.1007/BF01391443.
We studied the effect of ergonovine maleate (EM) on esophageal motor activity in 18 consecutive patients with angina-like chest pain. Significant coronary artery disease was excluded in each patient by cardiac catheterization studies. Baseline esophageal motility was abnormal in 12 patients (66%). After injection of EM, ten patients developed their typical chest pain at the onset of repetitive contractions. Thus, chest pain and esophageal dysfunction were clearly linked. Compared with saline injection, only the repetitive contractions were significantly increased after AM in these patients (P less than 0.01). Amplitude and duration of contractions were increased after EM, but not significantly. Due to potentially serious adverse effects, however, EM cannot be recommended for routine use as a provocative agent.
我们研究了马来酸麦角新碱（EM）对18例连续性心绞痛样胸痛患者食管运动活性的影响。通过心导管检查排除了每位患者的严重冠状动脉疾病。12例患者（66%）的基线食管动力异常。注射EM后，10例患者在重复性收缩开始时出现典型胸痛。因此，胸痛与食管功能障碍明显相关。与注射生理盐水相比，这些患者注射EM后仅重复性收缩显著增加（P<0.01）。EM注射后收缩幅度和持续时间增加，但不显著。然而，由于可能存在严重不良反应，不推荐将EM作为激发剂常规使用。
