链脲佐菌素诱导的糖尿病大鼠脂肪组织中的脂蛋白脂肪酶活性

Lipoprotein lipase activity in adipose tissue of streptozotocin-induced diabetic rats.

作者信息

Ishikawa A, Murase T, Yamada N, Tanaka K, Iwamoto Y, Akanuma Y, Ohsawa N

出版信息

Endocrinol Jpn. 1982 Jun;29(3):379-81. doi: 10.1507/endocrj1954.29.379.

DOI:10.1507/endocrj1954.29.379

Abstract

Lipoprotein lipase activity of epididymal adipose tissue was measured in streptozotocin-induced diabetic rats. Diabetic rats of 3, 10 and 34 days duration were examined. The enzyme activity in adipose tissue of diabetic rats was similar to that of control rats of the same ages, compared on the tissue weight basis. However, since adipose tissue weight was markedly reduced in rats with both acute and chronic diabetes, total enzyme activity in the whole tissue was very low in such animals regardless of the duration of diabetes. We wish to point out that contradictory results on the adipose tissue lipoprotein lipase activity in diabetic rats in the previous reports have arisen depending on differences in the methods chosen to express enzyme activity.

摘要

在链脲佐菌素诱导的糖尿病大鼠中测量附睾脂肪组织的脂蛋白脂肪酶活性。对病程为3天、10天和34天的糖尿病大鼠进行了检查。以组织重量为基础进行比较时，糖尿病大鼠脂肪组织中的酶活性与相同年龄的对照大鼠相似。然而，由于急性和慢性糖尿病大鼠的脂肪组织重量均显著降低，无论糖尿病病程长短，此类动物整个组织中的总酶活性都非常低。我们想指出的是，先前报告中关于糖尿病大鼠脂肪组织脂蛋白脂肪酶活性的矛盾结果，是由于选择表达酶活性的方法不同而产生的。