Baba H
Epilepsia. 1982 Dec;23(6):663-70. doi: 10.1111/j.1528-1157.1982.tb05082.x.
There are few reports on kindling preparation by daily electrical stimulation to the primary visual cortex. In our previous studies on cats, it was demonstrated that repeated stimulation to the primary visual cortex brought a similar progress in seizure development as in amygdaloid kindling, although it took more trials. In this study, we examined the effects of intermittent photic stimulation (IPS) (2.5 Hz) on the visual cortical kindling preparation to clarify more underlying mechanisms of photosensitivity. Under IPS, afterdischarges synchronizing to IPS were seen and a duration of afterdischarge was extremely prolonged, even in the early stage of the kindling process. The threshold of stimulus intensity inducing afterdischarge was significantly reduced and the generalized convulsive seizure was obtained with fewer times of stimulation, as compared to visual cortical kindling without IPS. In visual cortical kindling myoclonic responses were sometimes caused by IPS for a few minutes immediately after cessation of the electrically induced generalized seizure. Such phenomena were never seen in amygdaloid kindling. These results indicate that IPS facilitates a seizure development in all stages of visual cortical kindling.
关于通过每日对初级视觉皮层进行电刺激来制备点燃模型的报道很少。在我们之前对猫的研究中，已证明对初级视觉皮层的重复刺激在癫痫发作发展方面带来了与杏仁核点燃相似的进展，尽管需要更多的试验次数。在本研究中，我们研究了间歇性光刺激（IPS）（2.5赫兹）对视觉皮层点燃模型制备的影响，以阐明光敏性的更多潜在机制。在IPS作用下，即使在点燃过程的早期阶段，也能看到与IPS同步的后放电，并且后放电的持续时间极长。与无IPS的视觉皮层点燃相比，诱导后放电的刺激强度阈值显著降低，且通过较少次数的刺激即可获得全身性惊厥发作。在视觉皮层点燃中，在电诱导的全身性癫痫发作停止后几分钟内，IPS有时会引发肌阵挛反应。这种现象在杏仁核点燃中从未见过。这些结果表明，IPS在视觉皮层点燃的所有阶段都促进癫痫发作的发展。
