Ono K, Nakatsuka K, Baba H
Int J Neurosci. 1981;12(1):53-8. doi: 10.3109/00207458108990672.
The secondarily induced changes of brain function following seizure seen in kindling preparations were studied by means of the visually evoked potential (VEP) in unrestricted cats. The kindling was developed by repeated electrical stimulation to the visual cortex under intermittent photic stimulation (IPS). Generalized convulsion was rapidly developed with a lowering of threshold inducing afterdischarge and an earlier spreading of seizure discharge to the midbrain reticular formation as compared with the previous control experiment without IPS. Following electrical stimulation, a marked enhancement in amplitude and a prolongation in latency of the second negative component, which was not usually recognized before the electrical stimulation, was observed. Such augmentation of VEP developed progressively and finally changed into the epileptic discharge accompanied with myoclonic response. Furthermore, postictal augmentation of VEP which attained to maximum within a few minutes after the end of seizure was confirmed with an elevation of photosensitivity. It was noted that the second negative component continued significantly to exist for more than 60 min contrary to the relatively rapid restoration of the first negative component. These findings are discussed in relation to the mechanism of kindling phenomenon.
通过对未受限制的猫进行视觉诱发电位（VEP）研究，探讨了点燃模型中癫痫发作后大脑功能的继发性改变。点燃是通过在间歇性光刺激（IPS）下对视觉皮层进行重复电刺激来实现的。与之前没有IPS的对照实验相比，阈值降低诱发后放电，癫痫放电更快扩散到中脑网状结构，从而迅速发展为全身性惊厥。电刺激后，观察到第二个负波成分的幅度显著增强，潜伏期延长，而在电刺激之前通常无法识别该成分。VEP的这种增强逐渐发展，最终转变为伴有肌阵挛反应的癫痫放电。此外，癫痫发作后VEP的增强在癫痫发作结束后几分钟内达到最大值，并伴有光敏性升高。值得注意的是，与第一个负波成分相对较快恢复不同，第二个负波成分持续显著存在超过60分钟。结合点燃现象的机制对这些发现进行了讨论。
