Cotrufo R, Di Iorio G, Ammendola A, Bravaccio F
Eur Neurol. 1982;21(6):375-9. doi: 10.1159/000115508.
We describe a case presenting continuous muscle fiber activity syndrome, which was slightly reduced by the blocking of nerve conduction and abolished by ischemia. Clinical, electromyographical and bioptical evidence of marked abnormalities of peripheral motoneurons were observed. Association with central motoneuron lesions was suspected due to the observation of initial pyramidal signs. Therapy with diphenylhydantoin and/or carbamazepine resulted only in discrete amelioration of the syndrome. This case, which presented similarities as well as differences to the cases described by Isaacs and to those reported by other authors after 1961, stimulates a critical discussion of the already raised problem of the clinical heterogeneity of continuous muscle fiber activity syndrome.
我们描述了一例表现为持续性肌纤维活动综合征的病例，该综合征经神经传导阻滞稍有减轻，缺血后则消失。观察到周围运动神经元明显异常的临床、肌电图和活检证据。由于观察到初始锥体束征，怀疑与中枢运动神经元病变有关。使用苯妥英钠和/或卡马西平治疗仅使该综合征有轻微改善。该病例与艾萨克斯所描述的病例以及1961年后其他作者报道的病例既有相似之处，也有不同之处，这引发了对持续性肌纤维活动综合征临床异质性这一已提出问题的批判性讨论。
