Werneck L C, Caropreso V
Arq Neuropsiquiatr. 1984 Sep;42(3):251-61. doi: 10.1590/s0004-282x1984000300009.
Report of two adult males, 31 and 24 years-old, with hypertrophy in their left inferior limb, with denervation in the electromyography. Both patients undergone to a muscle biopsy in the normal and in the enlarged limb, which were processed by histochemistry. The mean muscle fiber diameter, percentage of muscle type fibers and atrophy and hypertrophy factors were calculated, as well as histographic fiber analysis. We found rare atrophic muscle fibers and one of the patients had hypertrophy of type II muscle fiber and the other hypertrophy of both types. The calculation of the atrophy and hypertrophy factors, revealed a predominance of type II fiber hypertrophy in both quadriceps of the two patients and type I hypertrophy in one case. A discussion about the factor responsible by the hypertrophy in denervation is made. The possible etiology of one case was a S1 radiculopathy and in the other, a possible motor neuron disease.
报告两名成年男性，年龄分别为31岁和24岁，左下肢肥大，肌电图显示失神经支配。两名患者均在正常肢体和肿大肢体上进行了肌肉活检，并进行了组织化学处理。计算了平均肌纤维直径、肌纤维类型百分比以及萎缩和肥大因子，还进行了组织学纤维分析。我们发现罕见的萎缩性肌纤维，其中一名患者II型肌纤维肥大，另一名患者两种类型均肥大。萎缩和肥大因子的计算显示，两名患者股四头肌中均以II型纤维肥大为主，一例为I型肥大。讨论了失神经支配时肥大的相关因素。其中一例可能的病因是S1神经根病，另一例可能是运动神经元病。
