大鼠全肝切除术的显微外科方法。
A microsurgical method for total hepatectomy in the rat.
作者信息
Holmin T, Alinder G, Herlin P
出版信息
Eur Surg Res. 1982;14(6):420-7. doi: 10.1159/000128316.
A microsurgical three-stage-procedure for total hepatectomy in the rat is described. In the first stage, suprarenal ligature and division of the inferior vena cava is performed. A modified portacaval shunt is constructed in the second stage and total hepatectomy is performed in the third stage. Microsurgical technique is of great benefit in both the second and third stages, especially in choosing the proper location for the shunt and minimizing blood loss. All the rats survived to the 6-hour study and 65% of the rats survived to the 18-hour study, despite the fact that body temperature was upheld to a level of 35-37 degrees C. Based on our experience in 165 hepatectomies, we recommend our method for metabolic studies in anhepatic rats.
本文描述了一种用于大鼠全肝切除的显微外科三阶段手术方法。第一阶段，进行肾上腺结扎和下腔静脉离断。第二阶段构建改良门腔分流术，第三阶段进行全肝切除。显微外科技术在第二和第三阶段都非常有用，特别是在选择分流的合适位置和减少失血方面。尽管将体温维持在35 - 37摄氏度，但所有大鼠都存活至6小时研究阶段，65%的大鼠存活至18小时研究阶段。基于我们在165例肝切除术中的经验，我们推荐我们的方法用于无肝大鼠的代谢研究。
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