McQuade P S, Juorio A V
Eur J Pharmacol. 1982 Sep 24;83(3-4):277-82. doi: 10.1016/0014-2999(82)90261-8.
The concentrations of p-tyramine (p-TA), m-tyramine (m-TA), dopamine (DA) and their principal metabolites, p-hydroxyphenylacetic acid (p-HPAA), m-hydroxyphenylacetic acid (m-HPAA) and homovanillic acid (HVA) were determined in the corpus striatum of Swiss mice at various times after the subcutaneous administration of beta-phenylethylamine (PE) (50 mg/kg). Initially p-TA concentrations were reduced but rapid synthesis was apparent up to 2 h after PE administration. PE treatment increased m-TA and these increases reached significance at 1 and 8 h. PE caused a bimodal increase in p-HPAA and m-HPAA concentrations with the first peak observed at 0.5-1 h due to initial release of p-TA and m-TA. Rapid synthesis of p-TA and m-TA resulted in increased acid concentrations at 4 h. HVA concentrations were increased up to 1 h after PE administration. The synthesis of p-TA and m-TA is related to that of DA probably as a result of the activation of tyrosine hydroxylase. PE may serve as a precursor for p-TA synthesis when the endogenous PE concentration is greatly elevated.
在皮下注射β-苯乙胺（PE）（50mg/kg）后的不同时间，测定了瑞士小鼠纹状体内对酪胺（p-TA）、间酪胺（m-TA）、多巴胺（DA）及其主要代谢产物对羟基苯乙酸（p-HPAA）、间羟基苯乙酸（m-HPAA）和高香草酸（HVA）的浓度。最初，p-TA浓度降低，但在PE给药后2小时内，快速合成明显。PE处理使m-TA增加，这些增加在1小时和8小时时达到显著水平。PE导致p-HPAA和m-HPAA浓度出现双峰增加，由于p-TA和m-TA的初始释放，在0.5-1小时观察到第一个峰值。p-TA和m-TA的快速合成导致4小时时酸浓度增加。PE给药后1小时内HVA浓度增加。p-TA和m-TA的合成可能与DA的合成有关，这可能是酪氨酸羟化酶激活的结果。当内源性PE浓度大幅升高时，PE可能作为p-TA合成的前体。
