动作电位期间的分子事件和能量变化。
Molecular events and energy changes during the action potential.
作者信息
Margineanu D G, Schoffeniels E
出版信息
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3810-3. doi: 10.1073/pnas.74.9.3810.
Abstract
A novel interpretation of the existing data concerning the energy changes associated with nerve impulse propagation is proposed. The main conclusion is that the negative phrase ofthe initial heat of activity cannot be accounted for without recourse to conformational changes in membrane proteins. It stems from analyzing and computing the energy changes associated with ionic flows, capacitive currents, and structural changes in membrane gateways. A close quantitative agreement with microcalorimetric measurements was achieved.
摘要
本文提出了一种对现有数据的全新解读，这些数据与神经冲动传播相关的能量变化有关。主要结论是，如果不借助膜蛋白的构象变化，就无法解释活动初始热的负相。这一结论源于对与离子流、电容电流以及膜通道结构变化相关的能量变化进行分析和计算。该分析与微量热测量结果在数量上高度吻合。
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