Zimmet P, Canteloube D, Genelle B, LeGonidec G, Couzigou P, Peghini M, Charpin M, Bennett P, Kuberski T, Kleiber N, Taylor R
Diabetologia. 1982 Nov;23(5):393-8. doi: 10.1007/BF00260949.
The study of different ethnic groups living in the same physical environment provides the opportunity to examine interaction of genetic and environmental factors in the aetiology of diabetes mellitus. In rural New Caledonia, the prevalence of diabetes was higher in part-Polynesians than in Melanesians: males - 6.6 versus 0.5%; females - 6.3 versus 3.5% respectively. The prevalence of abnormal glucose tolerance (impaired glucose tolerance and diabetes) was 11.5 and 15.7% in part-Polynesian males and females, respectively, and 4.7 and 9.2% in Melanesian males and females. Mean age and degree of obesity in these ethnic groups were sufficiently similar to suggest that these factors played no significant role in the difference in diabetes prevalence. Furthermore, adjustment of relative risk of impaired glucose tolerance and diabetes for age and obesity indicated that the modest differences between groups were not responsible for the observed variation in diabetes prevalence. The differences in prevalence of impaired glucose tolerance and diabetes between Melanesians and part-Polynesians may be genetically determined, although the role of certain environmental factors other than obesity, e.g. differences in physical activity or qualitative aspects of diet, cannot be excluded.
对生活在相同自然环境中的不同种族群体进行研究，为考察遗传和环境因素在糖尿病病因学中的相互作用提供了契机。在新喀里多尼亚农村地区，部分波利尼西亚人的糖尿病患病率高于美拉尼西亚人：男性分别为6.6%和0.5%；女性分别为6.3%和3.5%。部分波利尼西亚男性和女性的糖耐量异常（糖耐量受损和糖尿病）患病率分别为11.5%和15.7%，美拉尼西亚男性和女性分别为4.7%和9.2%。这些种族群体的平均年龄和肥胖程度足够相似，表明这些因素在糖尿病患病率差异中未起显著作用。此外，对糖耐量受损和糖尿病的相对风险进行年龄和肥胖因素调整后表明，各组之间的微小差异并非导致所观察到的糖尿病患病率变化的原因。美拉尼西亚人和部分波利尼西亚人之间糖耐量受损和糖尿病患病率的差异可能由基因决定，尽管除肥胖外某些环境因素的作用，如体力活动差异或饮食质量方面的差异，也不能排除。
