Radha Bai S, Rai U C, Thombre D P
Indian J Physiol Pharmacol. 1982 Jul-Sep;26(3):215-20.
Lever pressing rate under a continuous reinforcement schedule for food reward in rats was reduced significantly by cyproheptadine in the dose of 5 and 10 mg/kg body weight. Under fixed ratio schedule of reinforcement, the responding was also suppressed significantly by 5 and 10 mg/kg body weight doses of cyproheptadine. However, high dose (20 mg/kg) of cyproheptadine administered subsequent to the low doses, failed to inhibit the bar pressing rate under either continuous or fixed ratio schedules.
体重剂量为5毫克/千克和10毫克/千克的赛庚啶可显著降低大鼠在食物奖励连续强化程序下的杠杆按压率。在固定比率强化程序下，体重剂量为5毫克/千克和10毫克/千克的赛庚啶也能显著抑制反应。然而，在低剂量之后给予高剂量（20毫克/千克）的赛庚啶，无论是在连续强化程序还是固定比率强化程序下，都无法抑制杠杆按压率。
