Graeff F G
Psychopharmacology (Berl). 1976 Oct 20;50(1):65-71. doi: 10.1007/BF00634157.
Effects of the tryptamine antagonist, cyproheptadine, as well as of amphetamine, chlordiazepoxide, and combinations of cyproheptadine with amphetamine on lever-pressing behavior of rats were determined. A multiple, fixed-interval, 2 min fixed-ratio, 15 response schedule of water presentation was used. The three drugs affected fixed-interval fixed-ratio responding in a rate-dependent way, lower rates being more increased whereas higher rates were relatively more decreased. Cyproheptadine increased low response rates to a lesser extent than amphetamine, but increased high response rates that were little affected or only decreased by amphetamine. The combination of cyproheptadine and amphetamine increased response rates to a higher extent than either of the drugs alone. In addition, the rate-suppressant effects of the highest doses of amphetamine were also enhanced by cyproheptadine. These results show that cyproheptadine can increase nonpunished responding and suggest that cyproheptadine and amphetamine act synergistically, but through different mechanisms, upon multiple fixed-interval fixed-ratio performance.
测定了色胺拮抗剂赛庚啶以及苯丙胺、氯氮卓，还有赛庚啶与苯丙胺的组合对大鼠压杆行为的影响。采用了一种多重、固定间隔2分钟、固定比率15次反应的水呈现时间表。这三种药物以速率依赖的方式影响固定间隔固定比率反应，较低的反应速率增加得更多，而较高的反应速率相对下降得更多。赛庚啶增加低反应速率的程度小于苯丙胺，但增加了高反应速率，而高反应速率受苯丙胺的影响很小或仅有所下降。赛庚啶和苯丙胺的组合比单独使用任何一种药物都能更大程度地提高反应速率。此外，赛庚啶还增强了最高剂量苯丙胺的速率抑制作用。这些结果表明，赛庚啶可以增加非惩罚性反应，并表明赛庚啶和苯丙胺在多重固定间隔固定比率表现上协同作用，但通过不同机制起作用。
