Holmberg P C, Hernberg S, Kurppa K, Rantala K, Riala R
Int Arch Occup Environ Health. 1982;50(4):371-6. doi: 10.1007/BF00377833.
A cumulative case-referent study concerning selected exposures during pregnancy among mothers to children born with oral clefts has been in progress in Finland since December 1, 1977. The present study covering the initial 3.5 years' material can be regarded as a specific, more detailed extension of earlier retrospective studies concerning environmental factors in the causation of oral clefts, using material accumulated from the Finnish Register of Congenital Malformations. Information on exposures was gained by personal interviews with all the mothers. The analysis of different exposures and the classification of the material were performed blindly. Significantly more case-mothers than referent-mothers had been exposed to organic solvents during the first trimester of pregnancy (P less than 0.05).
自1977年12月1日起，芬兰一直在进行一项关于腭裂患儿母亲孕期特定暴露情况的累积病例对照研究。本研究涵盖了最初3.5年的资料，可视为早期关于腭裂病因环境因素的回顾性研究的具体、更详细的扩展，使用的是从芬兰先天性畸形登记处积累的资料。通过对所有母亲进行个人访谈获取暴露信息。对不同暴露情况的分析和资料分类是在盲态下进行的。与对照母亲相比，病例母亲在孕期头三个月接触有机溶剂的比例显著更高（P<0.05）。
