Patterson J W, Fitzwater J E
Int J Dermatol. 1982 Oct;21(8):476-80. doi: 10.1111/j.1365-4362.1982.tb03187.x.
A patient with hypopigmented sarcoidosis involving the face was treated with topical 8-methoxypsoralen and long wave ultraviolet light. Satisfactory repigmentation occurred within eight months of tri-weekly therapy. Electron microscopic study of involved, untreated skin showed abnormalities of melanocytes, including cytoplasmic vacuolization and the presence of melanosome complexes. Treated skin showed sparsity of melanosomes within the central portions of some melanocytes and large numbers of melanosomes within melanocytic dendrites. The clinical and ultrastructural findings suggest the possibility of toxic damage to melanocytes, perhaps with abnormalities of melanosome transfer, in lesions of hypopigmented sarcoidosis. These abnormalities appear to be responsive to psoralen-UVA therapy.
一名面部患有色素减退性结节病的患者接受了外用8-甲氧基补骨脂素和长波紫外线治疗。每周三次治疗八个月内出现了令人满意的色素沉着。对未治疗的受累皮肤进行电子显微镜研究，发现黑素细胞存在异常，包括细胞质空泡化和黑素小体复合物的存在。治疗后的皮肤显示，一些黑素细胞中央部分的黑素小体稀少，而黑素细胞树突内有大量黑素小体。临床和超微结构研究结果表明，色素减退性结节病的病变中黑素细胞可能受到毒性损伤，可能伴有黑素小体转运异常。这些异常似乎对补骨脂素-紫外线A疗法有反应。
