Gariot P, Seurot J M, Pointel J P, Contet-Audonneau J L, Gay G, Drouin P, Debry G
Hum Nutr Clin Nutr. 1982;36(5):351-61.
We studied the histological structure of the livers of 36 patients presenting type IV primary hyperlipoproteinaemia. Electron microscopy revealed dilation of the smooth endoplasmic reticulum and rough endoplasmic reticulum as well as the presence of giant mitochondria containing para-crystalline inclusions. Steatosis was present in all type IV hyperlipoproteinaemic patients regardless of their weight or nutritional sensitivity (to alcohol or carbohydrate). The ultrastructural modifications observed by electron microscopy indicate an increased synthesis of very-low-density lipoproteins by the hepatocytes. An alteration in excretion cannot be ruled out with certainty even though the microfilamentary microtubular system was intact, since the qualitative and functional modifications in this system may be undetectable by electron microscopy.
我们研究了36例IV型原发性高脂蛋白血症患者肝脏的组织学结构。电子显微镜检查显示，滑面内质网和粗面内质网扩张，以及存在含有副结晶包涵体的巨型线粒体。所有IV型高脂蛋白血症患者均存在脂肪变性，无论其体重或营养敏感性（对酒精或碳水化合物）如何。电子显微镜观察到的超微结构改变表明肝细胞合成极低密度脂蛋白增加。即使微丝微管系统完整，也不能确定排除排泄改变，因为该系统的定性和功能改变可能无法通过电子显微镜检测到。
