Shapiro S S, Dyer R D, Colás A E
Am J Obstet Gynecol. 1978 Nov 1;132(5):549-54. doi: 10.1016/0002-9378(78)90751-2.
The relative potency of six commonly used synthetic progestins has been evaluated in an organ culture system for human endometrium. The affinities of these progestins for endometrial progesterone receptor were also evaluated after removing the CBG-like protein by spheroidal hydroxylapatite chromatography. All six progestins induced an increase in tissue glycogen during culture at lower concentrations than did progesterone; only one (medroxyprogesterone acetate) had a relative affinity greater than progesterone. The relative potencies and affinities of the synthetic progestins were found to have the same relative order but to differ in relative magnitude.
已在人子宫内膜器官培养系统中评估了六种常用合成孕激素的相对效价。通过球状羟基磷灰石色谱法去除类皮质类固醇结合球蛋白（CBG）样蛋白后，还评估了这些孕激素对子宫内膜孕酮受体的亲和力。与孕酮相比，所有六种孕激素在较低浓度培养时均能诱导组织糖原增加；只有一种（醋酸甲羟孕酮）的相对亲和力大于孕酮。发现合成孕激素的相对效价和亲和力具有相同的相对顺序，但相对大小不同。
