Kaifu K, Komai T
J Biomed Mater Res. 1982 Nov;16(6):757-66. doi: 10.1002/jbm.820160602.
Various acylated chitins, including formyl, acetyl, propionyl, butyryl, caproyl, capryl, lauroyl, and benzoylchitin, were evaluated as materials for blood contact surfaces by means of contact angle and blood-clotting time measurements. Critical surface tensions of acylated chitins varied within the range of 20-30 dyn cm-1 and were dependent on the length of the acyl side chains. Furthermore, the dispersion and nondispersion components of the surface tension show remarkable differences which are dependent on the type of acyl group attached to chitin. The chitin derivative with 2.0 acetyl groups per N-acetylglucosamine residue gave values of the dispersive and nondispersive components of the surface tension that are very close to those obtained for glutaraldehyde-treated umbilical cord vessels. All of the acylated chitin surfaces show longer clotting times than the original chitin surface.
通过接触角和凝血时间测量，对包括甲酰化、乙酰化、丙酰化、丁酰化、己酰化、辛酰化、月桂酰化和苯甲酰化几丁质在内的各种酰化几丁质作为血液接触表面材料进行了评估。酰化几丁质的临界表面张力在20 - 30达因/厘米范围内变化，并取决于酰基侧链的长度。此外，表面张力的分散和非分散成分表现出显著差异，这取决于连接到几丁质上的酰基类型。每个N - 乙酰葡糖胺残基含有2.0个乙酰基的几丁质衍生物的表面张力分散和非分散成分的值与戊二醛处理的脐带血管所获得的值非常接近。所有酰化几丁质表面的凝血时间都比原始几丁质表面长。
