Watson R L, Langford H G
J Chronic Dis. 1982;35(12):909-18. doi: 10.1016/0021-9681(82)90122-9.
One hundred and seventy-nine Negro females, originally seen in high school in 1965, were visited at home during the summers of 1968 or 1969, and were revisited at home during 1978 or 1979. Weight, blood pressure, and urinary electrolyte excretion rates were obtained during the 1968-1969 studies. This report relates the previous measurements to the current (follow-up) blood pressure levels. 52 of the 179 have been told by a physician that they have high blood pressure, and 16 are now taking antihypertensive medication. The group now on medication were 27 lbs heavier and had higher blood pressures, 123/76 vs 114/70 in 1968-1969 than the remainder of the cohort, and their 24-hr urinary sodium excretion rate was greater, 5.9 vs 4.4 mEq/hr (p = 0.06). Among the groups now on therapy, the overnight K rate and Na/Ca ratio were inversely related to the 1968-1969 diastolic BP and the 24-hr Na rate and Na/K ratio were positively correlated with the 1968-1969 blood pressure, both systolic and diastolic. These associations were diminished when partial correlation coefficients adjusted for weight were calculated. Similar associations were not observed among the remainder of the cohort, suggesting that among persons who have the propensity to become hypertensive, the influence of factors which may produce hypertension such as sodium and/or obesity is more easily discernible.
1965年最初在高中被观察的179名黑人女性，于1968年或1969年夏天接受了家访，并在1978年或1979年再次接受家访。在1968 - 1969年的研究中获取了体重、血压和尿电解质排泄率。本报告将先前的测量结果与当前（随访）血压水平相关联。179名女性中有52名被医生告知患有高血压，16名正在服用抗高血压药物。目前正在服药的这组女性比队列中的其余女性重27磅，血压更高，1968 - 1969年时为123/76，而其余女性为114/70，并且她们的24小时尿钠排泄率更高，分别为5.9与4.4毫当量/小时（p = 0.06）。在目前接受治疗的组中，夜间钾排泄率和钠/钙比值与1968 - 1969年的舒张压呈负相关，24小时钠排泄率和钠/钾比值与1968 - 1969年的收缩压和舒张压均呈正相关。当计算经体重调整的偏相关系数时，这些关联减弱。在队列的其余部分未观察到类似的关联，这表明在有患高血压倾向的人群中，诸如钠和/或肥胖等可能导致高血压的因素的影响更容易辨别。
