Sixsmith D G, Watkins W M, Kokwaro G O
J Clin Hosp Pharm. 1982 Sep;7(3):205-7. doi: 10.1111/j.1365-2710.1982.tb01024.x.
The stability of adrenaline ophthalmic solutions, at pH 5.8 and 7.4, to sterilization and storage conditions has been studied. Solutions sterilized by filtration or heating at 98 degrees C for 30 min showed no detectable degradation at either pH value, whilst sterilization at higher temperatures resulted in losses of up to 30%. Total degradation increased with increasing sterilization temperature at both pH values.
