Kubota T, Yaoi Y, Suzuki A, Nishi N, Saito M, Kumasaka T
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Oct;34(10):1675-83.
In this paper, we revealed the changes in maternal plasma concentration of PRL, HCG, HPL, progesterone (P), estradiol-17 beta (E2), estriol (E3), estetrol (E4) and dehydroepiandrosterone-sulfate (DHEA-S) after the administration of bromocriptine during pregnancy. Blood samples were collected from 23 women with gestation ranging from 7 to 28 weeks. Sixteen patients had therapeutic abortion and other 7 patients had inevitable abortion. PRL, HCG, HPL, P, E2, E3, E4 and DHEA-S were measured by radioimmunoassay. The PRL decreased significantly at 120 and 180 minutes after the administration of bromocriptine in any case. In 4 cases out of 10 cases in early normal pregnancy, plasma E2 level decreased to 50% lower than the basal level, but no significant change of E2 occurred after bromocriptine in early and mid pregnancy. Bromocriptine made no change in HCG, HPL, P, E3, E4 and DHEA-S for any group. Our data suggested that bromocriptine had effect on only plasma PRL level, and this drug or the change of PRL level had no effect on P, estrogen, DHEA-S, HPL and HCG concentration during pregnancy.
在本文中，我们揭示了孕期服用溴隐亭后母体血浆中催乳素（PRL）、人绒毛膜促性腺激素（HCG）、人胎盘催乳素（HPL）、孕酮（P）、雌二醇-17β（E2）、雌三醇（E3）、雌四醇（E4）和硫酸脱氢表雄酮（DHEA-S）浓度的变化。从23名孕周为7至28周的女性中采集血样。16例患者进行了治疗性流产，另外7例患者为难免流产。采用放射免疫分析法测定PRL、HCG、HPL、P、E2、E3、E4和DHEA-S。无论何种情况，服用溴隐亭后120和180分钟时PRL均显著下降。在早孕正常的10例患者中有4例，血浆E2水平降至比基础水平低50%，但在早孕期和中孕期服用溴隐亭后E2无显著变化。溴隐亭对任何组的HCG、HPL、P、E3、E4和DHEA-S均无影响。我们的数据表明，溴隐亭仅对血浆PRL水平有影响，且这种药物或PRL水平的变化对孕期P、雌激素、DHEA-S、HPL和HCG浓度无影响。
