TambyRaja R L, Salmon J A
N Z Med J. 1977 Jul 27;86(592):89-92.
Peripheral plasma levels of the biologically important hormones of pregnancy--plasma oestradiol 17 beta, plasma oestriol, plasma progesterone, human placental lactogen (hPL) and human chorionic gonadotrophin (hCG) have been measured serially in a control group of 10 normal women who delivered at term +/- three days. A second group of patients were similarly studied when admitted in premature labour and the levels compared with the control group. The levels of all hormones except human chorionic gonadotrophin increased till 37 weeks. After the 30th week, the increase of oestriol was steeper than oestradiol and hPL. The hormone profile of the maternal plasma is a good index of feto-placental function. The hPL levels which heralded the increase in endocrine function of the feto-placental unit were also elevated in premature labour, suggesting a casual relationship of significance. Levels of plasma oestradiol in premature labour were considerably higher than in the control study and suggests an endocrine basis for premature labour of hitherto unknown aetiology.
对10名足月（±3天）分娩的正常女性组成的对照组，连续测定了妊娠期间具有重要生物学意义的激素的外周血浆水平，包括血浆17β-雌二醇、血浆雌三醇、血浆孕酮、人胎盘催乳素（hPL）和人绒毛膜促性腺激素（hCG）。对第二组早产入院的患者进行了类似研究，并将其水平与对照组进行比较。除人绒毛膜促性腺激素外，所有激素水平在37周前均升高。30周后，雌三醇的升高比雌二醇和hPL更显著。母体血浆中的激素谱是胎儿-胎盘功能的良好指标。在早产中，预示胎儿-胎盘单位内分泌功能增加的hPL水平也升高，提示存在显著的因果关系。早产时血浆雌二醇水平显著高于对照研究，提示迄今病因不明的早产存在内分泌基础。
