人类黑色素瘤抗原AH是一种与GD2相关的自身抗原性神经节苷脂。
Human melanoma antigen AH is an autoantigenic ganglioside related to GD2.
作者信息
Watanabe T, Pukel C S, Takeyama H, Lloyd K O, Shiku H, Li L T, Travassos L R, Oettgen H F, Old L J
出版信息
J Exp Med. 1982 Dec 1;156(6):1884-9. doi: 10.1084/jem.156.6.1884.
Abstract
AH antigen, initially defined by an antibody present in a melanoma patient, is a cell surface antigen found on approximately 65% of melanoma cell lines. Absorption analysis indicates that AH is a differentiation antigen marking normal and malignant cells of neuroectodermal origin. The AH determinant has been found to be related to GD2 ganglioside.
摘要
AH抗原最初由一名黑色素瘤患者体内存在的一种抗体所定义，是一种在约65%的黑色素瘤细胞系中发现的细胞表面抗原。吸收分析表明，AH是一种标记神经外胚层来源的正常细胞和恶性细胞的分化抗原。已发现AH决定簇与GD2神经节苷脂有关。
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