Goodlin R C
J Reprod Med. 1982 Oct;27(10):639-46.
It is argued that the physiologic anemia of midpregnancy is beneficial in terms of the associated hypervolemia and improved pregnancy outcome. Vigorous treatment of normal pregnant women having physiologic anemias with large doses of medicinal iron is discouraged because higher hematocrits are reported to be less efficient in terms of cardiac work and oxygen delivery, because lower serum iron levels protect against infection and because of the hazards of infant iron poisoning. Pharmacologic doses of iron also obscure the decline in hematocrit seen from the plasma volume expansion in normal pregnancy, removing a simple diagnostic sign of maternal hypovolemia.
有人认为，妊娠中期的生理性贫血在伴有血容量过多和改善妊娠结局方面是有益的。不鼓励对患有生理性贫血的正常孕妇大剂量使用药用铁进行积极治疗，因为据报道，较高的血细胞比容在心脏做功和氧气输送方面效率较低，较低的血清铁水平可预防感染，还因为存在婴儿铁中毒的风险。药理剂量的铁还会掩盖正常妊娠时因血浆量增加而出现的血细胞比容下降，消除了一个简单的母体血容量不足的诊断体征。
