Verster A, Tustin R C
J S Afr Vet Assoc. 1982 Sep;53(3):175-6.
The efficacy of Oncosphere Secretory Antigen (OSA) in protecting sheep against the larval stage of Taenia multiceps was assessed in 47 sheep in 2 trials. In the pilot trial no cerebral coenuri were found in 3 sheep which were treated with OSA 28 and 14 days before challenge with 6 000 eggs of T. multiceps. Cerebral coenuri were present in 3 untreated controls. In the second experiment 30 sheep were similarly treated with OSA and challenged with 5 000 eggs of T. multiceps, while 11 sheep served as untreated controls. At necropsy either developing coenuri or degenerate lesions were present in the brain of 5 (16,6%) of the 30 vaccinated animals while 8 out of 11 (72,7%) of the untreated animals had cerebral coenuri or degenerate lesions in the brain. It is concluded that OSA may be used to protect animals against cerebral coenuriosis.
在两项试验中，对47只绵羊评估了六钩蚴分泌抗原（OSA）保护绵羊抵御多头绦虫幼虫期感染的效果。在预试验中，3只在感染6000枚多头绦虫虫卵前28天和14天用OSA处理的绵羊未发现脑共尾蚴。3只未处理的对照羊出现了脑共尾蚴。在第二项试验中，30只绵羊同样用OSA处理并感染5000枚多头绦虫虫卵，11只绵羊作为未处理对照。尸检时，30只接种动物中有5只（16.6%）的脑内存在发育中的共尾蚴或退化性病变，而11只未处理动物中有8只（72.7%）脑内有脑共尾蚴或退化性病变。得出的结论是，OSA可用于保护动物预防脑共尾蚴病。
