Groce D F, Kimbrough R D
J Toxicol Environ Health. 1982 Sep;10(3):363-72. doi: 10.1080/15287398209530259.
Acute and subacute toxicity was studied in adult Sherman strain rats exposed to 4,4'-and 2,2'-dipyridyl. The single oral LD50 for 4,4'-dipyridyl was 175 mg/kg in male and 172 mg/kg in female rats; for 2,2'-dipyridyl it was 100 and 107 mg/kg, respectively. Symptoms of toxicity for 4,4'-dipyridyl included subdued behavior, red stains around mouth and eyes, lacrimation, swelling around the eyes, and occasional convulsions. Rats receiving 2,2'-dipyridyl had subdued behavior, loss of muscle coordination, red urine, tremors, and convulsions. Onset of symptoms was rapid, and most rats died from internal hemorrhage within 2 d after dosing. Rats given lower single oral doses of 90 mg/kg 2,2'-dipyridyl and 155 mg/kg 4,4'-dipyridyl had no symptoms and no organic pathology 2 wk after dosing. Rats given doses of 5.1 and 25.5 mg/kg 4,4'-dipyridyl and 7.13 and 35.6 mg/kg 2,2'-dipyridyl in their drinking water for 3 mo showed no significant effects that could be related to the consumption of dipyridyl.
在成年谢尔曼品系大鼠中研究了4,4'-联吡啶和2,2'-联吡啶的急性和亚急性毒性。4,4'-联吡啶的单次经口半数致死量在雄性大鼠中为175毫克/千克，在雌性大鼠中为172毫克/千克；2,2'-联吡啶的单次经口半数致死量分别为100毫克/千克和107毫克/千克。4,4'-联吡啶的中毒症状包括行为抑制、口鼻和眼部周围出现红色斑痕、流泪、眼部周围肿胀以及偶尔的抽搐。接受2,2'-联吡啶的大鼠表现出行为抑制、肌肉协调性丧失、尿液变红、震颤和抽搐。症状发作迅速，大多数大鼠在给药后2天内死于内出血。给予较低单次经口剂量90毫克/千克的2,2'-联吡啶和155毫克/千克的4,4'-联吡啶的大鼠在给药2周后没有症状且无器质性病变。在饮用水中给予剂量为5.1和25.5毫克/千克的4,4'-联吡啶以及7.13和35.6毫克/千克的2,2'-联吡啶达3个月的大鼠未表现出与联吡啶摄入有关的显著影响。
