Jones R E, Aulerich R J, Ringer R K
J Toxicol Environ Health. 1982 Sep;10(3):459-71. doi: 10.1080/15287398209530268.
Adult mink were fed various concentrations of supplemental iodine, ranging from 10 to 320 ppm, for 1 or 7 mo before breeding. Long-term, low-level (10-20 ppm) iodine supplementation was beneficial for both reproduction and lactation. Supplemental iodine in excess of 80 ppm, however, resulted in a reduction in the number of females that whelped, a decrease in litter size, and an increase in kit mortality. Thyroid glands of kits whelped and nursed by dams fed more than 20 ppm supplemental iodine, both short-term and long-term, showed hypertrophy marked by follicular cell hyperplasia and a decreased amount of colloid. Similar histopathologic lesions were observed in the thyroids of adults that received 80 ppm or more supplemental iodine; also observed were numerous lesions in the gallbladder.
成年水貂在繁殖前1个月或7个月被喂食各种浓度的补充碘，范围从10至320 ppm。长期低水平（10 - 20 ppm）补充碘对繁殖和哺乳都有益。然而，补充碘超过80 ppm会导致产仔母貂数量减少、窝仔数减少以及幼崽死亡率增加。由短期或长期喂食超过20 ppm补充碘的母貂所产并哺育的幼崽的甲状腺显示出肥大，其特征为滤泡细胞增生和胶体数量减少。在接受80 ppm或更多补充碘的成年水貂的甲状腺中也观察到了类似的组织病理学病变；在胆囊中也观察到了许多病变。
