Zincke H, Swanson S K
J Urol. 1982 Nov;128(5):913-5. doi: 10.1016/s0022-5347(17)53274-7.
Twenty-seven patients with synchronous (19 cases) or asynchronous (8 cases) bilateral renal cell carcinoma were treated and followed for as long as 20 years. Tumor grade and stage generally were more favorable in the former group, which is reflected in the higher surgical intervention rate. Nonsurgical treatment yielded poor results. The 5-year survival rate for patients with synchronous bilateral renal cell carcinoma (77.8 per cent) was significantly higher than that for patients with asynchronous lesions (37.5% per cent). Because of its different presentation and favorable prognosis when treated surgically synchronous bilateral renal cell cancer should be distinguished from the asynchronous form, with its dismal outcome. For the latter cases thorough long-term followup may make early surgical intervention feasible, and thus, improve patient survival.
27例同时性（19例）或异时性（8例）双侧肾细胞癌患者接受了治疗，并随访长达20年。前一组患者的肿瘤分级和分期通常更有利，这体现在更高的手术干预率上。非手术治疗效果不佳。同时性双侧肾细胞癌患者的5年生存率（77.8%）显著高于异时性病变患者（37.5%）。由于其表现不同，手术治疗时预后良好，因此应将同时性双侧肾细胞癌与异时性形式区分开来，后者预后不佳。对于后一种情况，进行全面的长期随访可能使早期手术干预可行，从而提高患者生存率。
