Takeuchi E, Abe T, Shimizu T, Murase M, Tanaka M, Nogaki H, Hotta A, Yano Y, Iyomasa Y
Jpn J Antibiot. 1982 Jul;35(7):1716-21.
The concentration of sulbenicillin in the serum and myocardial tissue of 13 patients were determined at cardiac surgery. About 100 mg/kg of sulbenicillin were administered intravenously for 60 minutes. Right auricle resected at the vena caval cannuration was examined for myocardial tissue. The serum concentration was also examined every 30 minutes after injection, 30 minutes, 60 minutes, 90 minutes, 120 minutes and 150 minutes. Mean values of serum concentration were 213.6 micrograms/ml, 432.5 micrograms/ml, 181.6 micrograms/ml, 236.3 micrograms/ml and 101 micrograms/ml, respectively. The values determined in myocardial tissue were 146.5 micrograms/g (60 minutes), 39.2 micrograms/g (90 minutes), 66.0 micrograms/g (120 minutes) and 23.5 micrograms/g (150 minutes). The mean value of concentration ratio of sulbenicillin in myocardial tissue was 0.23 of serum concentration. The high myocardial tissue levels of sulbenicillin suggests that its use at cardiovascular surgery would protect the myocardial tissue from the bacterial infections.
在心脏手术中测定了13例患者血清和心肌组织中的磺苄西林浓度。静脉注射约100mg/kg磺苄西林，持续60分钟。对腔静脉插管时切除的右心耳进行心肌组织检查。注射后每隔30分钟，即30分钟、60分钟、90分钟、120分钟和150分钟也进行血清浓度检查。血清浓度平均值分别为213.6微克/毫升、432.5微克/毫升、181.6微克/毫升、236.3微克/毫升和101微克/毫升。在心肌组织中测定的值分别为146.5微克/克（60分钟）、39.2微克/克（90分钟）、66.0微克/克（120分钟）和23.5微克/克（150分钟）。磺苄西林在心肌组织中的浓度与血清浓度的平均比值为0.23。磺苄西林在心肌组织中的高浓度表明，其在心血管手术中的应用可保护心肌组织免受细菌感染。
