磺苄西林钠的胎盘转运
Placental transfer of disodium sulbenicillin.
作者信息
Miyakawa I, Taniyama K, Inoue H, Lee H C, Mori N
出版信息
Antimicrob Agents Chemother. 1982 May;21(5):838-9. doi: 10.1128/AAC.21.5.838.
The concentrations of sulbenicillin in maternal and fetal blood and in the amniotic fluid compartment were measured in 27 women at parturition. With an intramuscular injection of 2,000 mg of sulbenicillin, the highest concentration of sulbenicillin in maternal blood (109.0 micrograms/ml) was attained at 55 min. The highest concentrations in umbilical cord blood (approximately 25 micrograms/ml) were attained between 1 and 3 h after dosage. The peak concentration in amniotic fluid (27.1 micrograms/ml) was attained approximately 7.5 h after sulbenicillin administration.
对27名分娩期妇女的母血、脐血和羊水样本中的磺苄西林浓度进行了测定。肌肉注射2000mg磺苄西林后，母血中磺苄西林的最高浓度（109.0μg/ml）在55分钟时达到。脐血中的最高浓度（约25μg/ml）在给药后1至3小时达到。羊水的峰值浓度（27.1μg/ml）在磺苄西林给药后约7.5小时达到。
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