Hepler B R, Solano R, Weber J R, Sunshine I, Konstan M W
J Anal Toxicol. 1982 Sep-Oct;6(5):258-9. doi: 10.1093/jat/6.5.258.
Thin-layer chromatography (TLC) was used to confirm the alleged ingestion of Loxitane (loxapine succinate) by a 20-month-old child. GC was used to further characterize TLC spots and to quantitate the loxapine concentration of the blood at 0.072 mg/dL, which was consistent with the child's presenting signs of lethargy and ataxia. The appropriate supportive symptomatic therapy, with monitoring for CNS and cardiovascular toxicities, resulted in an uneventful recovery.
采用薄层色谱法（TLC）来确认一名20个月大儿童是否摄入了氯氮平（琥珀酸洛沙平）。使用气相色谱法（GC）进一步鉴定TLC斑点，并对血液中的洛沙平浓度进行定量，结果为0.072mg/dL，这与该儿童出现的嗜睡和共济失调症状相符。采取适当的支持性对症治疗，并监测中枢神经系统和心血管毒性，患儿最终顺利康复。
