Peterson C D
Am J Psychiatry. 1981 Aug;138(8):1089-91. doi: 10.1176/ajp.138.8.1089.
The author reviewed records of 10 patients who had experienced acute loxapine overdose. The most frequent medical complications were CNS depression, sinus tachycardia, hypertension, and hypothermia; 6 patients had had generalized major motor seizures, 1 had had recurrent paroxysmal atrial tachycardia, and 2 had had transient renal insufficiency from rhabdomyolysis and myoglobinuria. Other clinical effects from loxapine overdose were predominantly anticholinergic. The author recommends that loxapine-overdose patients receive ECG monitoring and treatment of medical complications in an intensive care unit.
作者回顾了10例洛沙平急性过量患者的记录。最常见的医学并发症为中枢神经系统抑制、窦性心动过速、高血压和体温过低；6例患者发生全身性大发作，1例发生阵发性房性心动过速复发，2例因横纹肌溶解和肌红蛋白尿出现短暂性肾功能不全。洛沙平过量的其他临床影响主要为抗胆碱能作用。作者建议，洛沙平过量患者应在重症监护病房接受心电图监测并治疗医学并发症。
