人子宫组织（子宫内膜、子宫肌层和平滑肌瘤）中的雄烯二酮代谢

Androstenedione metabolism in human uterine tissues: endometrium, myometrium and leiomyoma.

作者信息

Jasonni V M, Bonavia M, Lodi S, Preti S, Bulletti C, Flamigni C

出版信息

J Steroid Biochem. 1982 Nov;17(5):547-51. doi: 10.1016/0022-4731(82)90014-0.

Abstract

Androstenedione was metabolized in vitro by human endometrium, myometrium and leiomyoma, to its 5 alpha-reduced metabolites: 5 alpha-androstan-3,17-dione (5 alpha-androstanedione) and androsterone as well as to testosterone, 17 beta-hydroxy-5 alpha-androstan-2-one (5 alpha-DHT) and 5 alpha-androstan-3 alpha,17 beta-diol (3 alpha-diol). Uterine tissue showed a similar enzymatic profile to the androgen responsive tissues; these data suggest that androgens may have a functional role in the uterine pathophysiology.

摘要

雄烯二酮在体外可被人子宫内膜、子宫肌层和平滑肌瘤代谢为其5α-还原代谢产物：5α-雄甾烷-3,17-二酮（5α-雄甾烷二酮）和雄酮，以及睾酮、17β-羟基-5α-雄甾烷-2-酮（5α-双氢睾酮）和5α-雄甾烷-3α,17β-二醇（3α-二醇）。子宫组织显示出与雄激素反应性组织相似的酶谱；这些数据表明雄激素可能在子宫病理生理学中发挥功能性作用。