Smith P G, Poston C W, Mills E
Life Sci. 1982 Aug 30;31(9):889-92. doi: 10.1016/0024-3205(82)90545-8.
In neonatal and young adult SH and WK rats, maturation of a functional unit consisting of sympathetic nerve terminals and smooth muscle (levator palpebrae) was assessed in vivo by measuring the contractile response to tyramine, an agent which releases endogenous norepinephrine from sympathetic nerve terminals. Responses in SH are comparable to WK at 5-6 days postnatally, smaller from the 8th through 19th day and larger in young adults (41-46 days old). Results indicate that functional maturation of the nerve terminal-smooth muscle complex is retarded in SH relative to WK during the 2nd and 3rd postnatal weeks. It is suggested that retardation in the neonatal SH rat is an expression of a genetic defect in the growth of the complex and that the enhanced response in young adult SH is a consequence of the neonatal abnormality.
在新生和年轻成年的SH和WK大鼠中，通过测量对酪胺的收缩反应，在体内评估了由交感神经末梢和平滑肌（提上睑肌）组成的功能单元的成熟情况。酪胺是一种能从交感神经末梢释放内源性去甲肾上腺素的物质。产后5 - 6天时，SH大鼠的反应与WK大鼠相当；从第8天到第19天，SH大鼠的反应较小；在年轻成年大鼠（41 - 46日龄）中，SH大鼠的反应较大。结果表明，在出生后第2周和第3周期间，相对于WK大鼠，SH大鼠神经末梢 - 平滑肌复合体的功能成熟受到延迟。有人提出，新生SH大鼠的延迟是该复合体生长中基因缺陷的一种表现，而年轻成年SH大鼠反应增强是新生异常的结果。
