Kuromi H
Eur J Pharmacol. 1978 Oct 1;51(3):285-9. doi: 10.1016/0014-2999(78)90413-2.
The development of sympathetic nerve--muscle transmission was investigated pharmacologically by using the nerve-expansor secundariorum muscle preparation of 2- to 35-day-old chicks. The nerve-induced muscle contraction was not affected by atropine and neostigmine after hatch but was slightly depressed by phentolamine and completely depressed by guanethidine. Since the responsiveness of the muscle to some adrenomimetic drugs remained constant after hatch, adrenergic receptor function does not change during development. The nerve-induced muscle response was scarcely influenced by cocaine or reserpine in neonatal chick while it was potentiated by cocaine and changed by reserpine in mature chicks. These results suggest that cocaine- and reserpine-sensitive mechanisms gradually develop in sympathetic nerve function after hatch. The presence of a potentiating effect of cocaine on the nerve-induced muscle response in dimethylphenylpiperazinium-treated neonatal chick suggests that the development of sympathetic nerve function is regulated by nerve activity itself.
利用2至35日龄雏鸡的副交感神经-肌肉扩张制备物，通过药理学方法研究交感神经-肌肉传递的发育。出壳后，神经诱导的肌肉收缩不受阿托品和新斯的明的影响，但受酚妥拉明的轻微抑制，并被胍乙啶完全抑制。由于出壳后肌肉对某些拟肾上腺素药物的反应性保持不变，因此肾上腺素能受体功能在发育过程中不会改变。新生雏鸡的神经诱导肌肉反应几乎不受可卡因或利血平的影响，而成雏鸡的神经诱导肌肉反应则被可卡因增强，被利血平改变。这些结果表明，可卡因和利血平敏感机制在出壳后的交感神经功能中逐渐发展。可卡因对经二甲基苯基哌嗪处理的新生雏鸡的神经诱导肌肉反应有增强作用，这表明交感神经功能的发育受神经活动本身的调节。
