5型腺病毒可诱导静止的大鼠细胞进入S期，且不伴有多胺积累。
Adenovirus type 5 induces progression of quiescent rat cells into S phase without polyamine accumulation.
作者信息
Cheetham B F, Shaw D C, Bellett A J
出版信息
Mol Cell Biol. 1982 Oct;2(10):1295-8. doi: 10.1128/mcb.2.10.1295-1298.1982.
Abstract
Adenovirus type 5 induces cellular DNA synthesis and thymidine kinase in quiescent rat cells but does not induce ornithine decarboxylase. We now show that unlike serum, adenovirus type 5 fails to induce S-adenosylmethionine decarboxylase or polyamine accumulation. The inhibition by methylglyoxal bis(guanylhydrazone) of the induction of thymidine kinase by adenovirus type 5 is probably unrelated to its effects on polyamine biosynthesis. Thus, induction of cellular thymidine kinase and DNA replication by adenovirus type 5 is uncoupled from polyamine accumulation.
摘要
5型腺病毒可诱导静止大鼠细胞中的细胞DNA合成和胸苷激酶，但不诱导鸟氨酸脱羧酶。我们现在表明，与血清不同，5型腺病毒不能诱导S-腺苷甲硫氨酸脱羧酶或多胺积累。5型腺病毒诱导胸苷激酶时，甲基乙二醛双（脒腙）的抑制作用可能与其对多胺生物合成的影响无关。因此，5型腺病毒诱导细胞胸苷激酶和DNA复制与多胺积累无关。
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