Menargues A, Obach R, Vallès J M
Mutat Res. 1984 May;136(2):127-9. doi: 10.1016/0165-1218(84)90154-x.
The bone-marrow micronucleus assay was used in mice to evaluate the mutagenic potential of cyanamide administered per os at doses of 10, 49 and 247 mg/kg. Bone-marrow smears were examined to find the incidence of micronucleated cells in 1000 polychromatic erythrocytes (PCE) and 1000 normochromatic erythrocytes ( NCE ). The ratio of NCE /PCE was also scored. No increase in the incidence of micronucleated polychromatic erythrocytes and no difference in the ratio NCE /PCE for the groups treated with cyanamide (10 and 49 mg/kg) were observed. The group treated with the highest dose of cyanamide (247 mg/kg) did, however, show an NCE /PCE ratio lower than the control group (p less than 0.05).
采用小鼠骨髓微核试验，以评估经口给予剂量为10、49和247mg/kg的氰胺的致突变潜力。检查骨髓涂片，以确定1000个多染性红细胞（PCE）和1000个正染性红细胞（NCE）中微核细胞的发生率。还对NCE/PCE比值进行了评分。未观察到用氰胺（10和49mg/kg）处理的组中多染性红细胞微核发生率增加，且NCE/PCE比值无差异。然而，用最高剂量氰胺（247mg/kg）处理的组的NCE/PCE比值低于对照组（p<0.05）。
