Emanuel N M, Ostrovskaya L A, Krutova T V
Neoplasma. 1982;29(5):597-603.
The kinetics of tumor growth and cell proliferation of eleven generations of spontaneous mammary carcinoma in F1(CBA2 X C57B1/6) mice was studied. Factors responsible for different sensitivity of tumors to 1-methyl-1-nitrosourea were analyzed. The process of tumor transplantation was accompanied by the reduction in latent period and the increase in the mean specific rate of tumor growth. The rise in tumor growth rate in consequent generations was associated with the increase of the number of DNA synthesizing cells. The fall in the intensity of the DNA synthesis was observed along with the tumor growth within one passage. The sensitivity of tumors to 1-methyl-1-nitrosourea was correlated reciprocally only with the initial labeling index of tumors and the specific rate of tumor growth.
研究了F1（CBA2×C57B1/6）小鼠11代自发性乳腺癌的肿瘤生长动力学和细胞增殖情况。分析了肿瘤对1-甲基-1-亚硝基脲不同敏感性的相关因素。肿瘤移植过程伴随着潜伏期缩短和肿瘤平均比生长率增加。后续代次肿瘤生长率的上升与DNA合成细胞数量的增加有关。在一个传代过程中，随着肿瘤生长，观察到DNA合成强度下降。肿瘤对1-甲基-1-亚硝基脲的敏感性仅与肿瘤的初始标记指数和肿瘤比生长率呈负相关。
