Ostrovskaia L A, Frankfurt O S
Vopr Onkol. 1977;23(2):88-93.
Single intrafemoral injection of NMU in the dosage of 80 mg/Kh in mice with ascites leucemia L1210 induced considerable disorders in the tumor cell cycle. The passage of phase S by cells was markedly retarded during the period from 1 hour to 6 days, while after injection of the substance under study a maximum duration of phase G2 increased from 4 to 12 hours. Inhibition of phase S onset was provisional, and already 6 hours following NMU injection all cells entered phase S. In mice mammary tumors the label index fell markedly (by 90%) during the period from 6 hours to 8 days after NMU injection. The intensity of 3H-thymidine incorporation during the whole period of observation was approximately twice reduced.
在患有腹水型白血病L1210的小鼠中，以80毫克/千克的剂量单次股内注射NMU可导致肿瘤细胞周期出现相当大的紊乱。在1小时至6天期间，细胞通过S期的过程明显延迟，而在注射所研究的物质后，G2期的最长持续时间从4小时增加到12小时。对S期起始的抑制是暂时的，在注射NMU后6小时，所有细胞就已进入S期。在小鼠乳腺肿瘤中，在注射NMU后6小时至8天期间，标记指数显著下降（下降90%）。在整个观察期内，3H-胸腺嘧啶核苷掺入的强度大约降低了一半。
