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去甲丙咪嗪、地西泮和氯甲西泮对人体生长激素刺激作用的比较。

Comparison of growth hormone stimulation induced by desimipramine, diazepam and metaclazepam in man.

作者信息

Laakmann G, Treusch J, Schmauss M, Schmitt E, Treusch U

出版信息

Psychoneuroendocrinology. 1982;7(2-3):141-6. doi: 10.1016/0306-4530(82)90006-3.

DOI:10.1016/0306-4530(82)90006-3
PMID:7178370
Abstract

A comparison of the effect on growth hormone (GH) stimulation in men (n = 6) of desimipramine (DMI), a tricyclic antidepressant, and of the benzodiazepine derivatives diazepam and metaclazepam with that of a placebo, showed that only DMI caused a significant (p less than 0.01) GH stimulation. After DMI, all six subjects showed a GH stimulation greater than 7.5 ng/ml, whereas after diazepam or metaclazepam, only three of the six subjects showed GH stimulation greater than 7.5 ng/ml, and the other three showed only a very small change, or no change at all in GH secretion. Higher GH stimulation occurred after diazepam (10 mg i.v.) than after diazepam (10 mg p.o.). No dose-dependent difference in GH stimulation after metaclazepam (10 and 30 mg p.o.) was apparent. No side effects appeared after administration of DMI during the test period (180 min); however, after administration of the benzodiazepine derivatives, sedative effects were clearly noted. DMI thus causes reliable GH stimulation in healthy male subjects, whereas GH stimulation could only be measured in some of the subjects after diazepam and metaclazepam.

摘要

比较三环类抗抑郁药去甲丙咪嗪(DMI)、苯二氮䓬衍生物地西泮和甲氯西泮对男性(n = 6)生长激素(GH)刺激的效果与安慰剂的效果,结果显示只有DMI引起了显著(p < 0.01)的GH刺激。服用DMI后,所有6名受试者的GH刺激均大于7.5 ng/ml,而服用地西泮或甲氯西泮后,6名受试者中只有3名的GH刺激大于7.5 ng/ml,另外3名受试者的GH分泌仅出现非常小的变化或根本没有变化。静脉注射地西泮(10 mg)后的GH刺激高于口服地西泮(10 mg)后的GH刺激。口服甲氯西泮(10 mg和30 mg)后,GH刺激没有明显的剂量依赖性差异。在测试期间(180分钟)服用DMI后未出现副作用;然而,服用苯二氮䓬衍生物后,明显出现了镇静作用。因此,DMI能在健康男性受试者中引起可靠的GH刺激,而地西泮和甲氯西泮仅能在部分受试者中检测到GH刺激。

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