Laakmann G, Benkert O, Neulinger E, Werder K, Erhardt F
Arzneimittelforschung. 1978;28(8):1292-4.
DMI leads to stimulation of GH in healthy male subjects 60--120 min after i.m. injection and 150--210 min after oral application. During a 20-day administration of 2 x 75 mg DMI per day a repeated stimulation of GH was provable on days 0, 10 and 20 in two male patients, whereas no stimulation of GH occurred in two female patients who underwent the same treatment. The GH basic secretion did not increase in any of the four after patients 10 and 20 days, respectively. Neither prolactin (PRL) nor thyreotrophin (TSH) serum concentrations are influenced by DMI. The increase in PRL and TSH, which is induced by the thyrotrophin releasing hormone (TRH), is provable after acute as well as after chronic administration of DMI.
在健康男性受试者中，肌内注射后60 - 120分钟以及口服给药后150 - 210分钟，二甲麦角新碱（DMI）会导致生长激素（GH）分泌增加。在两名男性患者中，每天给予2×75毫克DMI，持续给药20天，在第0、10和20天可反复观察到GH分泌增加，而接受相同治疗的两名女性患者未出现GH分泌增加。在这四名患者中，分别在10天和20天后，GH基础分泌均未增加。二甲麦角新碱对催乳素（PRL）和促甲状腺激素（TSH）的血清浓度均无影响。促甲状腺激素释放激素（TRH）诱导的PRL和TSH升高，在急性和慢性给予二甲麦角新碱后均可观察到。
