Borenstein D G, Fye W B, Arnett F C, Stevens M B
Ann Intern Med. 1978 Nov;89(5 Pt 1):619-24. doi: 10.7326/0003-4819-89-5-619.
Five patients with clinically overt myocarditis in the setting of systemic lupus erythematosus were analyzed in terms of associated clinical and serologic features. Myositis and antibodies to nuclear ribonucleoprotein (RNP) were present in all. A retrospective review in 140 consecutive patients with systemic lupus erythematosus, including three of these five, showed a highly significant association of myocarditis with myositis (P less than 0.0005). The presence of antibodies to RNP in this small group did not attain statistical significance (P less than or equal to 0.10). The pathologic findings in the one patient who died showed similar patterns of inflammation in both cardiac and skeletal muscle, suggesting the possibility of a generalized inflammatory process directed against striated muscle. Furthermore, although anti-RNP antibodies were found uniformly in these patients, their significance remains to be defined.
对五例患有系统性红斑狼疮且伴有临床明显心肌炎的患者，就相关临床和血清学特征进行了分析。所有患者均存在肌炎和抗核核糖核蛋白（RNP）抗体。对140例连续性系统性红斑狼疮患者（包括这五例中的三例）进行回顾性研究发现，心肌炎与肌炎之间存在高度显著相关性（P<0.0005）。在这个小群体中，RNP抗体的存在未达到统计学意义（P≤0.10）。死亡的那例患者的病理结果显示，心肌和骨骼肌存在相似的炎症模式，提示可能存在针对横纹肌的全身性炎症过程。此外，尽管在这些患者中均发现了抗RNP抗体，但其意义仍有待确定。
