Parrish C R, Oliver R E, McNiven R
Vet Microbiol. 1982 Sep;7(4):317-24. doi: 10.1016/0378-1135(82)90011-6.
A serological study of canine parvovirus (CPV) infections in a colony of dogs was conducted over a period of 8 months. Twenty-two of 24 adults samples initially had significant antibody titres to CPV. Nine litters of puppies were bled at fortnightly intervals and the sera tested for antibodies to CPV. Twenty-nine of 35 naturally PV infections observed were subclinical. A puppy in one litter developed vomiting and diarrhoea during the same period as seroconversion to CPV. Four puppies from a further litter developed histologically confirmed myocarditis. Serological testing of this latter litter indicated that the virus infections occurred between 2 weeks prior to and 1 week post whelping, and that clinical disease developed 20-40 days after viral infection. The mean half life of the decline of passively derived immunity to CPV was 8.3 days.
在8个月的时间里，对一群犬进行了犬细小病毒（CPV）感染的血清学研究。24份成年犬样本中，最初有22份对CPV有显著抗体效价。9窝幼犬每隔两周采血一次，检测血清中CPV抗体。观察到的35例自然感染CPV病例中，29例为亚临床感染。一窝幼犬中的一只在血清转化为CPV的同一时期出现呕吐和腹泻。另一窝的4只幼犬经组织学证实患有心肌炎。对后一窝幼犬的血清学检测表明，病毒感染发生在分娩前2周和产后1周之间，临床疾病在病毒感染后20 - 40天出现。被动获得的针对CPV的免疫力下降的平均半衰期为8.3天。
